Dr. Keith Baar is a Professor on the College of California, Davis within the Division of Physiology and Membrane Biology.
Throughout his Ph.D. research, his analysis revealed that mechanical pressure on muscle fibers prompts the mammalian goal of rapamycin (mTOR) signaling pathway, an important regulator of muscular hypertrophy.
Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance coaching underneath the steering of Dr. John Holloszy, a legend within the discipline of train physiology, thought of the daddy of recent train biochemistry.
Constructing on all of this expertise, he performed analysis into tendon well being and the potential for engineering ligaments, which might have implications for therapy and restoration from accidents.
Dr. Baar now runs the Practical Molecular Biology Lab at UC Davis. His lab’s work ranges from finding out molecular adjustments in our cells to conducting research to impact real-world enhancements in individuals’s well being, longevity, and high quality of life.
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Dr. Keith Baar, UC Davis — Easy Workout routines That Can Restore Tendons (Tennis Elbow, and so on.), Collagen Truth vs. Fiction, Isometrics vs. Eccentrics, JAK Inhibitors, Progress Hormone vs. IGF-1, The Anti-RICE Protocol, and The right way to Use Load as an Anti-Inflammatory
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Wish to hear one other episode that explores the probabilities of rapamycin? Have a take heed to the dialog I had with Peter Attia, David M. Sabatini, and Navdeep S. Chandel on the supply of this miraculous compound: Easter Island. Right here, we focus on how probably the most necessary discoveries of medical science was nearly misplaced, why metabolism (together with longevity) analysis is essential to treating a protracted checklist of ailments, intermittent dosing of rapamycin, parenting recommendation from scientists on confidence and battle, the required failures of fine science, good fonts versus unhealthy fonts, “non-potato” relationships, and far more.
What was your favourite quote or lesson from this episode? Please let me know within the feedback.
SELECTED LINKS FROM THE EPISODE
- Join with Dr. Keith Baar:
Physiology & Biology
Power Physiology
Molecular Biology
Train Physiology
Damage & Restoration
Coaching & Rehabilitation Strategies
Substances & Interventions
Dietary supplements
Prescribed drugs
Orthobiologics (Critiqued)
Diets
Establishments & Locations
Motion pictures
Analysis
Related Assets
SHOW NOTES
- [00:07:12] How I found Keith’s work by a tweet about tennis elbow and mountaineering.
- [00:07:54] Emil Abrahamsson’s hangboard coaching protocol.
- [00:09:20] The basic rules of power coaching and connective tissue adaptation.
- [00:10:36] mTOR complicated 1 and its position in muscle development.
- [00:12:06] Engineered ligaments and the invention of minimal efficient doses for tendon adaptation.
- [00:13:50] The refractory interval between optimum tendon loading periods.
- [00:16:42] Rapamycin’s results on muscle hypertrophy.
- [00:18:49] Protocols for tennis elbow rehabilitation.
- [00:20:28] Why isometrics work higher than eccentrics for tendon therapeutic.
- [00:22:14] Stress shielding and the way load distribution impacts tendon therapeutic.
- [00:29:07] The misperception about eccentric loading for tendon accidents and why velocity issues.
- [00:29:58] Perfect period for isometric holds (10-30 seconds) primarily based on damage standing.
- [00:33:50] My elbow points and present rehab strategy.
- [00:36:02] Overcoming vs. yielding isometrics and optimum loading methods.
- [00:47:11] Dr. Barr’s motion prescription for my tennis elbow.
- [00:52:18] Loading timing post-surgery and RICE protocol criticism.
- [00:56:58] Achilles tendon rehabilitation after surgical procedure.
- [01:00:18] Critique of orthopedic suturing methods and advice for resorbable sutures.
- [01:04:02] A number of place isometrics for tennis elbow rehabilitation.
- [01:07:26] Collagen synthesis, supplementation, and vitamin C timing.
- [01:12:59] Critique of BPC-157 and different injectable peptides for tendon therapeutic.
- [01:18:19] Analysis of orthobiologics’ (PRP, prolotherapy, stem cells) effectiveness.
- [01:21:37] JAK-STAT inhibitor medicine and their results on tendon development.
- [01:25:35] Medication that enhance danger of tendon ruptures (fluoroquinolones, AT-1 receptor medicine).
- [01:29:33] How estrogen impacts tendon stiffness and damage danger in ladies.
- [01:32:48] Testosterone’s reverse results on tendon in comparison with estrogen.
- [01:35:31] Protein consumption suggestions and timing.
- [01:40:11] Ketogenic weight loss program results on mitochondrial biogenesis and longevity.
- [01:41:57] Comparability of ketogenic weight loss program, low protein weight loss program, and rapamycin for longevity.
- [01:47:19] Irritation’s position in adaptation and when to cut back it.
- [01:51:17] Timing of ice baths relative to coaching for optimum restoration.
- [01:52:33] Parting ideas.
MORE DR. KEITH BAAR QUOTES FROM THE INTERVIEW
“The primary value to the US medical system is definitely musculoskeletal sprains, strains and tears, the again and the neck, in addition to the remainder of the physique. It’s greater than diabetes and coronary heart illness mixed.”
— Dr. Keith Baar
“If passive flexibility was actually necessary for reducing tendon damage, then the ladies’s gymnasts who’ve essentially the most passive flexibility wouldn’t be the NCAA sport with the best fee of Achilles tendon rupture.”
— Dr. Keith Baar
“Damage associated to flexibility is a U-shaped curve. So our accidents are actually excessive once we’re very rigid. After we get into that candy spot the place now we have good mobility, we will do the total vary of movement, really the damage fee could be very low. If we change into hyper-mobile, we even have that damage fee go up as properly.”
— Dr. Keith Baar
“We don’t use a ketogenic weight loss program if we wish to go quick, but when we’re coaching for all times, we see that it will increase longevity, that the ketones themselves are actually good for mind perform.”
— Dr. Keith Baar
“The primary recorded immobilizer for an ankle or a leg is from Egyptian hieroglyphs the place they confirmed photos 4,500 years in the past. If I took you and also you mentioned you had most cancers, you wouldn’t desire a therapy that was developed 4,500 years in the past. You’d hope that one thing new has been developed within the final 4,500 years. That’s the place we’re for our orthopedic conditions.”
— Dr. Keith Baar
“The truth is that there are particularly sure athletes like climbers the place they’re doing all types of heavy lifts, they’re doing all types of heavy work, they’re doing all types of actually dynamic strikes. And what occurs, what breaks down is that they break down of their finger tendons they usually break down within the little pulleys throughout the tendons.”
— Dr. Keith Baar
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